Postattachment events associated with viral entry are necessary for induction of interferon-stimulated genes by human cytomegalovirus.

نویسندگان

  • James R Netterwald
  • Thomas R Jones
  • William J Britt
  • Shao-Jun Yang
  • Ian P McCrone
  • Hua Zhu
چکیده

Utilizing a human cytomegalovirus-specific fusion inhibitor and an antiglycoprotein H antibody, we studied the role of virion fusion in interferon-stimulated gene (ISG) induction. Our results indicate that ISG induction does not occur when virion-mediated, post-high-affinity attachment events are inhibited by either reagent. Thus, virion-mediated postattachment events, such as fusion, are required for ISG induction.

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عنوان ژورنال:
  • Journal of virology

دوره 78 12  شماره 

صفحات  -

تاریخ انتشار 2004